FIGfam

From NMPDR Wiki

A FIGfam is a set of genes that perform the same functional role.

The first step in constructing FIGfams is to take all gene from a single column of a subsystem spreadsheet. This gives us all genes that perform a specific task in a known metabolic pathway. Most of the The initial set of genes In other words, a FIGfam is a set of genes that perform a single functional role in a known metabolic pathway. Additional genes are added to the family by examining similarities in close strains.

Most of the proteins in a FIGfam are homologous, but this does not need to be the case. If two proteins perform the same function, they belong in the same FIGfam even though they may have radically different structures.